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Optic nerve disorders
OPTIC NERVE & VISUAL FUNCTION
Clinical observation and mechanistic research focusing on compressive optic neuropathy, optic nerve sheath fenestration, and preservation of visual function.
OPHTHALMOLOGY & OCULOPLASTICS
Hui Chen
Hui ChenProfessor · Ophthalmology and OculoplasticsDedicated to ophthalmology,
exploring the balance of function and aesthetics.
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Orbital and oculoplastic surgery
From optic nerve protection to orbital reconstruction, and from clinical questions to basic research,
continuing to explore greater precision in ophthalmic care and oculoplastic practice.
VISION. PRECISION. UNDERSTANDING.Scroll to explore
01 / ABOUT
In the finest details,
seeing new possibilities.
Clinical insight.
Scientific curiosity.
Hui Chen, Professor of Ophthalmology.
Focusing on optic nerve disorders, orbital disorders, and oculoplastics,
connecting clinical practice with medical research.
Engaged in clinical and academic ophthalmology at Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, with professional interests in optic nerve sheath fenestration, thyroid eye disease, traumatic enophthalmos, and periocular plastic and reconstructive surgery.
Completed postdoctoral research in cell and molecular biology at the University of Oklahoma Health Sciences Center and Dean McGee Eye Institute in the United States. His research extends to ocular lymphatics and cerebrospinal fluid circulation, orbital fat metabolism, retinal protection, and computer vision-assisted assessment.
02 / EXPERTISE
Grounded in clinical practice,
continually deepening specialist expertise.
Bringing together eye function, tissue repair, and morphological assessment
in interconnected areas of clinical practice and research.
02
Orbital disorders and reconstruction
ORBITAL DISEASE & RECONSTRUCTION
Focusing on thyroid eye disease, traumatic enophthalmos, and orbital hollowing, with clinically informed research into tissue metabolism and repair.
03
Oculoplastic and periocular reconstruction
OCULOPLASTICS & PERIORBITAL REPAIR
Focusing on upper eyelid hollowing, periocular morphology, and tissue repair, with research into autologous fat grafting and more objective methods of morphological assessment.
04
Translational ophthalmology and biomedical engineering
TRANSLATIONAL & INTERDISCIPLINARY
Connecting medicine and technology through work on ocular lymphatics, sphingolipid metabolism, neuroprotection, computer vision-assisted assessment, and intelligent surgical imaging.
03 / SELECTED PUBLICATIONS
Research that responds to clinical questions.
10 selected publications
2013—2025
2013—2025
RESEARCH SPOTLIGHT
Thyroid eye disease
and adipogenesis
Epigenetics × Orbital disordersStarting with cellular mechanisms
Starting with cellular mechanisms
to understand changes in orbital fat.
Investigating the roles of LSD1 and histone H3K9 demethylation in adipogenesis in thyroid eye disease, connecting clinical observations with experimental research.
Read the original research012025
Epigenetic mechanisms of adipogenesis in thyroid eye disease
LSD1 induces H3 K9 demethylation to promote adipogenesis in thyroid-associated ophthalmopathy
Investigating the relationship between LSD1-mediated histone modification and orbital adipogenesis to provide experimental evidence for understanding disease mechanisms.
022025
Objective assessment of upper eyelid hollowing using computer vision
A computer vision-based framework for objective evaluation of sunken upper eyelid
Introducing image feature analysis into periocular morphological assessment and investigating a single-image framework for evaluating upper eyelid hollowing.
032025
Advances in research on ocular and nasal lymphatic systems
Advances in the Understanding of ocular and nasal lymphatics
Reviewing the anatomy, function, and research on ocular and nasal lymphatic systems to offer perspectives on local drainage and immune connections.
042024
Spaceflight-associated neuro-ocular syndrome and the optic nerve cerebrospinal fluid outflow hypothesis
Hypothesis on the outflow of optic nerve cerebrospinal fluid in spaceflight associated neuro ocular syndrome
Proposing a mechanistic hypothesis involving cerebrospinal fluid outflow along the optic nerve and discussing possible connections with neuro-ophthalmic problems in microgravity.
052023
Metabolic characteristics of orbital adipose tissue in thyroid eye disease
Metabolic features of orbital adipose tissue in patients with thyroid eye disease
Using metabolomics to investigate changes in orbital adipose tissue associated with thyroid eye disease.
062023
Long-term retrospective clinical observations of optic nerve sheath fenestration
Optic Nerve Sheath Fenestration for Progressive Visual Loss in Cerebral Venous Sinus Thrombosis: A Long-Term Retrospective Observational Study
Reviewing surgical and follow-up data for patients with cerebral venous sinus thrombosis and progressive visual loss.
Show 4 more selected publicationsShow fewer publications
072023
Exploring potential interventions through a patient-derived preclinical platform
Repurposing picropodophyllin as a potential thyroid eye disease treatment via delaying mitotic clonal expansion through a patient-derived preclinical platform
Investigating the effects of picropodophyllin on cell proliferation and differentiation using patient-derived preclinical models.
082022
Advances in research on brain and ocular lymphatic systems
Progress on Brain and Ocular Lymphatic System
Summarizing advances in research on brain and ocular lymphatic systems, with a focus on anatomical connections and related disease mechanisms.
092017
Advances in the use of optic nerve sheath fenestration
Update on the application of optic nerve sheath fenestration
A review of indications, surgical techniques, and advances in clinical research on optic nerve sheath fenestration.
102013
Sphingolipid metabolism and experimental retinal neuroprotection
Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration
Investigating the relationship between ceramide synthesis and retinal degeneration in a rat model of light-induced injury.
The Chinese titles serve as reading guides. Please refer to the original journal articles for the full English titles, author details, and research findings.
04 / PROFESSIONAL JOURNEY
A professional journey,
marked by experience.
From international research experience to clinical and scientific practice,
and onward to innovation at the intersection of medicine and engineering.
POSTDOCTORAL FELLOWSHIP ↗University of Oklahoma Health Sciences CenterDean A. McGee Eye Institute
- 2009—2011INTERNATIONAL FELLOWSHIP
Postdoctoral research in the United States
Completed postdoctoral research in cell and molecular biology at the Department of Ophthalmology, University of Oklahoma Health Sciences Center, and Dean A. McGee Eye Institute from April 2009 to May 2011.
- 2013BASIC RESEARCH
Investigating retinal injury and neuroprotection
Published research on sphingolipid metabolism and experimental retinal protection as first author in the Journal of Lipid Research; received an Outstanding Paper Award at the 2nd National Neuro-ophthalmology Conference.
- 2017CLINICAL RESEARCH
Continuing research on optic nerve sheath fenestration
Published a review of advances in optic nerve sheath fenestration; received third prize in the Young Investigator Outstanding Paper Competition at the Chinese Medical Association's 14th Academic Conference on Medical Aesthetics.
- 2022CLINICAL RECOGNITION
Ren Tinggui Surgical Award
Received Shanghai General Hospital's 2022 Gongji Award for Outstanding Clinical Work — the Ren Tinggui Surgical Award, presented in 2023.
- 2024—2025MEDICINE & ENGINEERING
Advancing collaboration between medicine and engineering
Contributed to projects on an intelligent focusing surgical camera system and an ultra-realistic electronic ocular prosthesis, which received a Bronze Award at the National Invention Exhibition and a Silver Award at the China (Shanghai) International Invention and Innovation Exhibition, respectively.
PROFESSIONAL SERVICE
Medical Aesthetics and Art Branch, Chinese Association of Plastics and AestheticsAppointed Standing Council Member of the 2nd Council · Three-year term beginning July 2023, as stated on the certificate
Minimally Invasive Aesthetics and Anti-aging Branch, Sichuan Association of Aesthetic and Plastic SurgeryFormer Vice President · 2018–2023
05 / INNOVATION & RECOGNITION
Bringing ideas into practice.
At the intersection of clinical needs in ophthalmology and engineering,
continuing to explore possibilities for innovation.
View certificate ↗2025 · SILVER AWARD
Award recipients: Hui Chen, Doudou Qin, and Yan Yan
Ultra-realistic electronic ocular prosthesis
Project: “Ultra-realistic electronic ocular prosthesis that simulates the movement of the healthy eye”
Silver Award, 8th China (Shanghai) International Invention and Innovation Exhibition
Award recipient institution: Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineAward recipients: Hui Chen, Doudou Qin, and Yan Yan
View certificate ↗2024 · BRONZE AWARD
Hui Chen is one of the project's inventors
Intelligent focusing surgical camera system
Project: “Human–machine collaborative surgical camera system with intelligent, human-eye-like focusing”
Bronze Award, 28th National Invention Exhibition and the Belt and Road and BRICS Skills Development and Technology Innovation Competition
Award recipient institution: Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineHui Chen is one of the project's inventors
06 / ACADEMIC EXCHANGE
Through dialogue,
broadening perspectives in medicine.
Sharing clinical observations and discussing research advances.
Continuing to reflect and learn through dialogue with colleagues.
Academic exchange on the orbit and optic nerve
Sharing clinical observations on optic nerve sheath fenestration and optic neuropathies.
Chinese Society of Plastic Surgery, Chinese Medical Association
22nd Academic Meeting
1st National Medical Aesthetics Conference
CLINICAL INSIGHT. SCIENTIFIC CURIOSITY.